Oncolytic adenovirus-mediated p53 gene transfer induces antitumor effect in human bone and soft tissue sarcoma cells

ثبت نشده
چکیده

in human bone and soft tissue sarcoma cells +Hasei, J; Sasaki, T; Tazawa, H; Hashimoto, Y; Kunisada, T; Yoshida, A; Urata, Y Ozaki, T; Fujiwara, T +Department of Orthopedic Surgery, Okayama University, Department of Orthopedic Surgery, Hasegawa Kinen Hospital, Center for Gene and Cell Therapy, Okayama University Hospital, Department of Gastroenterological Surgery, Okayama University. Department of Medical Materials for Musculoskeletal Reconstruction, Okayama University, Oncolys BioPharma, Inc. [email protected]

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas.

PURPOSE Tumor-specific replication-selective oncolytic virotherapy is a promising antitumor therapy for induction of cell death in tumor cells but not of normal cells. We previously developed an oncolytic adenovirus, OBP-301, that kills human epithelial malignant cells in a telomerase-dependent manner. Recent evidence suggests that nonepithelial malignant cells, which have low telomerase activi...

متن کامل

Cancer Therapy: Preclinical Preclinical Evaluation of Telomerase-Specific Oncolytic Virotherapy for Human Bone and Soft Tissue Sarcomas

Purpose: Tumor-specific replication-selective oncolytic virotherapy is a promising antitumor therapy for induction of cell death in tumor cells but not of normal cells. We previously developed an oncolytic adenovirus, OBP-301, that kills human epithelial malignant cells in a telomerase-dependent manner. Recent evidence suggests that nonepithelial malignant cells, which have low telomerase activ...

متن کامل

Telomerase-Specific Replication-Selective Virotherapy for Bone and Soft Tissue Sarcomas

INTRODUCTION: Bone and soft tissue sarcomas represent a small percentage of cancers worldwide; however, they are the third most children cancer in United States. Despite major advances in the treatment of advanced bone and soft tissue sarcomas such as the introduction of novel chemotherapy regimens, therapy fails in about one fourth of the patients. Therefore, to treat the patients with advance...

متن کامل

Cancer Therapeutics Insights Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Tumor suppressor p53 is a multifunctional transcription factor that regulates diverse cell fates, including apoptosis and autophagy in tumor biology. p53 overexpression enhances the antitumor activity of oncolytic adenoviruses; however, the molecular mechanism of this occurrence remains unclear. We previously developed a tumor-specific replication-competent oncolytic adenovirus, OBP-301, that k...

متن کامل

Potent antitumor activity of oncolytic adenovirus expressing mda-7/IL-24 for colorectal cancer.

It has been demonstrated that interleukin 24 (IL-24, also called melanoma differentiation associated gene 7) exerts antitumor activity. In this study, we investigated whether oncolytic adenovirus-mediated gene transfer of IL-24 could induce strong antitumor activity. A tumor-selective replicating adenovirus expressing IL-24 (ZD55-IL-24) was constructed by insertion of an IL-24 expression casset...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011